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Loss of CD4+ T cells in human immunodeficiency virus type 1-infected chimpanzees is associated with increased lymphocyte apoptosis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Davis, Ian C. Girard, M. L. Fultz, Patricia N. |
| Copyright Year | 1998 |
| Abstract | Supportive evidence that apoptosis contributes to loss of CD4+ lymphocytes in human immunodeficiency virus type 1 (HIV-1)-infected humans comes from an apparent lack of abnormal apoptosis in apathogenic lentivirus infections of nonhuman primates, including HIV-1 infection of chimpanzees. Two female chimpanzees were inoculated, one cervically and the other intravenously, with HIV-1 derived from the LAI/LAV-1b strain, which was isolated from a chimpanzee infected with the virus for 8 years. Within 6 weeks of infection, both recipient chimpanzees developed a progressive loss of CD4+ T cells which correlated with persistently high viral burdens and increased levels of CD4+ T-cell apoptosis both in vitro and in vivo. Lymph nodes from both animals also revealed evidence of immune hyperactivation. Intermediate levels of T-cell apoptosis in both peripheral blood and lymph nodes were seen in a third chimpanzee that had been infected with the LAI/LAV-1b strain for 9 years; this animal has maintained depressed CD4/CD8 T-cell ratios for the last 3 years. Similar analyses of cells from 4 uninfected animals and 10 other HIV-1-infected chimpanzees without loss of CD4+ cells revealed no difference in levels of apoptosis in these two control groups. These results demonstrate a correlation between immune hyperactivation, T-cell apoptosis, and chronic loss of CD4+ T cells in HIV-1-infected chimpanzees, providing additional evidence that apoptosis is an important factor in T-cell loss in AIDS. Furthermore, the results show that some HIV-1 strains are pathogenic for chimpanzees and that this species is not inherently resistant to HIV-1-induced disease. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/jvi.72.6.4623-4632.1998 |
| PubMed reference number | 9573225 |
| Journal | Medline |
| Volume Number | 72 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://jvi.asm.org/content/72/6/4623.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/jvi.72.6.4623-4632.1998 |
| Journal | Journal of virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
