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Increased loss of CCR5+ CD45RA- CD4+ T cells in CD8+ lymphocyte-depleted Simian immunodeficiency virus-infected rhesus monkeys.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Veazey, Ronald S. Acierno, Paula M. McEvers, Kimberly J. Baumeister, Susanne H. Foster, Gabriel J. Rett, Melisa D. Newberg, Michael H. Kuroda, Marcelo J. Williams, Kenneth Kim, Eun-Young Wolinsky, Steven M. Rieber, Ernst Peter Piatak, Michael Lifson, Jeffrey D. Montefiori, David C. Brown, Charles R. Hirsch, Vanessa M. Schmitz, Joern E. |
| Copyright Year | 2008 |
| Abstract | Previously we have shown that CD8(+) T cells are critical for containment of simian immunodeficiency virus (SIV) viremia and that rapid and profound depletion of CD4(+) T cells occurs in the intestinal tract of acutely infected macaques. To determine the impact of SIV-specific CD8(+) T-cell responses on the magnitude of the CD4(+) T-cell depletion, we investigated the effect of CD8(+) lymphocyte depletion during primary SIV infection on CD4(+) T-cell subsets and function in peripheral blood, lymph nodes, and intestinal tissues. In peripheral blood, CD8(+) lymphocyte-depletion changed the dynamics of CD4(+) T-cell loss, resulting in a more pronounced loss 2 weeks after infection, followed by a temporal rebound approximately 2 months after infection, when absolute numbers of CD4(+) T cells were restored to baseline levels. These CD4(+) T cells showed a markedly skewed phenotype, however, as there were decreased levels of memory cells in CD8(+) lymphocyte-depleted macaques compared to controls. In intestinal tissues and lymph nodes, we observed a significantly higher loss of CCR5(+) CD45RA(-) CD4(+) T cells in CD8(+) lymphocyte-depleted macaques than in controls, suggesting that these SIV-targeted CD4(+) T cells were eliminated more efficiently in CD8(+) lymphocyte-depleted animals. Also, CD8(+) lymphocyte depletion significantly affected the ability to generate SIV Gag-specific CD4(+) T-cell responses and neutralizing antibodies. These results reemphasize that SIV-specific CD8(+) T-cell responses are absolutely critical to initiate at least partial control of SIV infection. |
| File Format | PDF HTM / HTML |
| DOI | 10.1128/JVI.02748-07 |
| PubMed reference number | 18367534 |
| Journal | Medline |
| Volume Number | 82 |
| Issue Number | 11 |
| Alternate Webpage(s) | http://jvi.asm.org/content/82/11/5618.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1128/JVI.02748-07 |
| Journal | Journal of virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
