NDLI: Development and validation of a modified QuEChERS protocol coupled to LC-MS/MS for simultaneous determination of multi-class antibiotic residues in honey.

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Development and validation of a modified QuEChERS protocol coupled to LC-MS/MS for simultaneous determination of multi-class antibiotic residues in honey.

Content Provider	Semantic Scholar
Author	Shendy, Amr H. Al-Ghobashy, Medhat A. Alla, Sohair A. Gad Lotfy, Hayam Mahmoud
Copyright Year	2016
Abstract	LC-MS/MS assay was developed and validated according to EU guidelines for determination of nitrofuran metabolites and nitroimidazole residues in honey. Crude samples were acid-treated to liberate matrix-bound residues and a modified QuEChERS protocol was employed. Nitrofurantoin, furazolidone, furaltadone and nitrofurazone were determined via analysis of their metabolites AHD, AOZ, AMOZ and SEM, respectively while nitroimidazole residues; ronidazole (RNZ) and dimetridazole (DMZ) were determined directly. For all analytes, neat standard calibration curves, after correction for matrix effect were successfully employed. Decision limit (CCα) and detection capability (CCβ) were below the MRPL for nitrofurans (1.00 μg kg(-1)) and the recommended concentration for nitroimidazole (3.00 μg kg(-1)), respectively. The CCα, CCβ, percentage recovery and CV% ranges were 0.12-0.74 μg kg(-1), 0.21-1.27 μg kg(-1), 90.96-104.80% and 2.65-12.58%, respectively. This work is part of the national initiative for establishing a national monitoring program for drug residues in Egyptian honey.
Starting Page	982
Ending Page	989
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.foodchem.2015.06.048
PubMed reference number	26213065
Journal	Medline
Volume Number	190
Alternate Webpage(s)	https://www.fue.edu.eg/pdfFiles/Publications/Hayam_Mahmoud_Lotfy_Ibrahim_Mahmoud_25692.pdf
Alternate Webpage(s)	https://doi.org/10.1016/j.foodchem.2015.06.048
Journal	Food chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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