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Cordyceps sinensis inhibits airway remodeling in rats with chronic obstructive pulmonary disease
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yang, Lei Jiao, Xingai Wu, Jinxiang Zhao, Jiping Liu, Tian Xu, Jianfeng Ma, Xiaohui Cao, Liuzao Liu, Lin Liu, Yahui Chi, Jingyu Zou, Minfang Li, Shuo Xu, Jiawei Dong, Liang |
| Copyright Year | 2018 |
| Abstract | Cordyceps sinensis is a traditional Chinese herbal medicine that has been used for centuries in Asia as a tonic to soothe the lung for the treatment of respiratory diseases. The aim of the present study was to determine the effects of C. sinensis on airway remodeling in chronic obstructive pulmonary disease (COPD) and investigate the underlying molecular mechanisms. Rats with COPD were orally administered C. sinensis at low, moderate or high doses (2.5, 5 or 7.5 g/kg/day, respectively) for 12 weeks. Airway tissue histopathology, lung inflammation and airway remodeling were evaluated. C. sinensis treatment significantly ameliorated airway wall thickening, involving collagen deposition, airway wall fibrosis, smooth muscle hypertrophy and epithelial hyperplasia in model rats with COPD. Additionally, C. sinensis administration in rats with COPD reduced inflammatory cell accumulation and decreased inflammatory cytokine production, including tumor necrosis factor-α, interleukin-8 and transforming growth factor (TGF)-β1 in bronchoalveolar lavage fluid. Meanwhile, the increased levels of α-smooth muscle actin and collagen I in the COPD group were also markedly decreased by C. sinensis treatment. Furthermore, compared with untreated rats with COPD, C. sinensis reduced the expression level of phosphorylated (p)-Smad2, p-Smad3, TGF-β1 and its receptors, with the concomitant increased expression of Smad7 in the lungs of rats with COPD. These results indicated that treatment with C. sinensis may be a useful approach for COPD therapy. |
| Starting Page | 2731 |
| Ending Page | 2738 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/etm/15/3/2731/download |
| PubMed reference number | 29456676v1 |
| Alternate Webpage(s) | https://doi.org/10.3892/etm.2018.5777 |
| DOI | 10.3892/etm.2018.5777 |
| Journal | Experimental and therapeutic medicine |
| Volume Number | 15 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bronchoalveolar Lavage Fluid Chronic Obstructive Airway Disease Collagen Diseases Cordyceps sinensis (fungus) Cordyceps sinensis preparation Fibrosis Gram per Kilogram per Day Histopathology Irrigation Lung Diseases, Obstructive Lung diseases Oral cavity Pneumonitis Respiration Disorders Smooth muscle (tissue) Structure of parenchyma of lung Tonic-Clonic Epilepsy Transforming Growth Factors cytokine smooth muscle hypertrophy tumor necrosis |
| Content Type | Text |
| Resource Type | Article |
