NDLI: Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease.

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Type I collagenases in bronchoalveolar lavage fluid from preterm babies at risk of developing chronic lung disease.

Content Provider	Semantic Scholar
Author	Sweet, David G. McMahon, Kimberly Curley, Anna Elizabeth O'Connor, Clare M. Halliday, Henry L.
Copyright Year	2001
Abstract	OBJECTIVE To assess whether increased collagenolysis precedes severe chronic lung disease (CLD). METHODS Matrix metalloproteinase-1 (MMP-1) and MMP-8 (enzymes that degrade type I collagen, the main structural protein of lung extracellular matrix) were measured by enzyme linked immunosorbent assay in 100 bronchoalveolar lavage samples taken during the first 6 postnatal days from 45 ventilated preterm babies < 33 weeks gestation. The median value for each baby was calculated. CLD was defined as an oxygen requirement after the 36th week after conception. RESULTS MMP-8 levels in bronchoalveolar lavage fluid were higher (median 13 ng/ml) in 20 babies who developed CLD than in 25 without CLD (median 2 ng/ml). No MMP-1 was detected in any sample. CONCLUSIONS MMP-8 can be detected in bronchoalveolar lavage fluid from preterm babies, and higher levels are found in those who later develop CLD. MMP-8 may contribute to lung injury that occurs as a prelude to CLD.
Starting Page	CD003603
Ending Page	CD003603
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://fn.bmj.com/content/fetalneonatal/84/3/F168.full.pdf
PubMed reference number	11320042v1
Volume Number	84
Issue Number	3
Journal	Archives of disease in childhood. Fetal and neonatal edition
Language	English
Access Restriction	Open
Subject Keyword	Bronchoalveolar Lavage Fluid COLLAGENASE Chronic lung disease Enzyme-Linked Immunosorbent Assay Extracellular Matrix Infant Irrigation Lung Injury Lung diseases Microgram per Liter Oxygen Pregnancy Structure of parenchyma of lung
Content Type	Text
Resource Type	Article

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