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Targeted therapy in breast cancer: the HER-2/neu gene and protein.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ross, Jeffrey S. Fletcher, Jonathan Alfred Bloom, Kenneth J. Linette, Gerald P. Stec, James P. Symmans, W. Fraser Pusztai, Lajos Hortobagyi, Gabriel N. |
| Copyright Year | 2004 |
| Abstract | The HER-2/neu oncogene, a member of the epidermal growth factor receptor or erb gene family, encodes a transmembrane tyrosine kinase receptor that has been linked to prognosis and response to therapy with the anti-HER-2-humanized monoclonal antibody, trastuzumab (Herceptin, Genentech, South San Francisco, CA) in patients with advanced metastatic breast cancer. HER-2/neu status has also been tested for its ability to predict the response of breast cancer to other therapies including hormonal therapies, topoisomerase inhibitors, and anthracyclines. This review includes an analysis of 80 published studies encompassing more than 25,000 patients designed to consider the relative advantages and disadvantages of the various methods of measuring HER-2/neu in clinical breast cancer specimens. Southern blotting, PCR amplification detection, and fluorescence in situ hybridization assays designed to detect HER-2/neu gene amplification are compared with HER-2/neu protein overexpression assays performed by immunohistochemical techniques applied to frozen and paraffin-embedded tissues and enzyme immunoassays performed on tumor cytosols. The significance of HER-2/neu overexpression in ductal carcinoma in situ and the HER-2/neu status in uncommon female breast conditions and male breast cancer are also considered. The role of HER-2/neu testing for the prediction of response to trastuzumab therapy in breast cancer is reviewed along with the current studies designed to test whether HER-2/neu status can predict the response to standard and newer hormonal therapies, cytotoxic chemotherapy, and radiation. The review will also evaluate the status of serum-based testing for circulating HER-2/neu receptor protein and its ability to predict disease outcome and therapy response. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.mcponline.org/content/3/4/379.full.pdf |
| PubMed reference number | 14762215v1 |
| Volume Number | 3 |
| Issue Number | 4 |
| Journal | Molecular & cellular proteomics : MCP |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anthracyclines Body tissue CDISC SDTM Disease Outcome Terminology Carcinoma breast stage IV Carcinoma in Situ Carcinoma of Male Breast Cytoplasmic matrix Cytotoxic Chemotherapy Ductal Breast Carcinoma ESR2 wt Allele Eighty Embedding Enzyme Immunoassay Fluorescence Fluorescent in Situ Hybridization Growth Factor Receptors Hormone Therapy Immunoassay method Mammary Neoplasms Monoclonal Antibodies Noninfiltrating Intraductal Carcinoma Nucleic Acid Hybridization Oncogene ErbB2 Oncogenes Patients Protein Overexpression Scientific Publication Southern blot assay (procedure) Specimen Therapeutic procedure Topoisomerase Inhibitors Tyrosine erbB-2 Receptor trastuzumab |
| Content Type | Text |
| Resource Type | Article |
