NDLI: Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts.

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Glucose-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts.

Content Provider	Semantic Scholar
Author	Podual, Kairali Doyle, Francis J. Peppas, Nicholas A.
Copyright Year	2000
Abstract	Glucose oxidase and catalase were immobilized on poly(diethylaminoethyl methacrylate-g-ethylene glycol) gels by copolymerization of the constituent monomers and the functionalized enzyme solutions. The hydrogels were prepared in the form of discs and microparticles. The amount and the activity of enzymes immobilized in the matrix were determined. The hydrogels were tested for their response to glucose by exposing microparticles to varying concentrations of glucose. The generation of gluconic acid as a result of the reaction of glucose with oxygen was investigated as a function of polymer parameters, such as crosslinking ratio and enzyme loading. Pulsatile variation of the glucose concentration was used to confirm the glucose-dependent swelling properties of these hydrogels.
Starting Page	9
Ending Page	17
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.che.utexas.edu/research/biomat/PDFReprints/JControlledRelease_67_9-17(2000).pdf
PubMed reference number	10773324v1
Volume Number	67
Issue Number	1
Journal	Journal of controlled release : official journal of the Controlled Release Society
Language	English
Access Restriction	Open
Subject Keyword	Amine Oxidase (Copper-Containing) CATALASE Copolymer Copolymerization Cross link GLUCOSE OXIDASE Gel Hydrogels Methacrylates Oxygen Polyethylene Glycols Polymers Solutions Transplanted tissue ethylene glycol gluconic acid monomer
Content Type	Text
Resource Type	Article

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