NDLI: Poly(ethylene glycol)-containing hydrogels in drug delivery.

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Poly(ethylene glycol)-containing hydrogels in drug delivery.

Content Provider	Semantic Scholar
Author	Peppas, Nicholas A. Keys, Kelley Britton Torres-Lugo, Madeline Lowman, Anthony M.
Copyright Year	1999
Abstract	The use of hydrogels as carriers for protein delivery has been a subject of significant recent research. In our recent work, we have shown that diffusion controlled delivery of proteins from hydrogels containing poly(ethylene glycol) (PEG) can be possible and controlled by the three-dimensional structure. In addition, a number of these hydrogel carriers are mucoadhesive and can be used for protein delivery. PEG star polymer gels have also been prepared by gamma-irradiation and have been used for protein delivery with and without molecular imprinting. The presence of a large number of functional groups in a small volume makes these polymers important for use in biological and pharmaceutical applications. PEG star polymer hydrogels were synthesized using gamma-irradiation and were characterized using swelling techniques. Equilibrium swelling studies were conducted to investigate the effects of molecular weight, number of star arms, concentration, and radiation dose.
Starting Page	1625
Ending Page	1626
Page Count	2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.che.utexas.edu/research/biomat/PDFReprints/JControlledRelease_62_81-87(1999).pdf
PubMed reference number	10518639v1
Volume Number	62
Issue Number	1-2
Journal	Journal of controlled release : official journal of the Controlled Release Society
Language	English
Access Restriction	Open
Subject Keyword	Alveolar rhabdomyosarcoma Drug Delivery Systems Edema GUCY2C protein, human Gel Hydrogel Hydrogels Imprinting (Psychology) Molecular Imprinting Molecular Weight Polyethylene Glycols Polymers
Content Type	Text
Resource Type	Article

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