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Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Micklefield, Jason |
| Copyright Year | 2001 |
| Abstract | Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole sugar phosphodiester with alternative anionic, neutral and cationic structures. Several of these modified oligonucleotides exhibit improved properties including enhanced recognition and binding to RNA, duplex DNA and proteins. This has resulted in the development of new and more potent antisense and antigene agents, as well as aptamers. Furthermore, backbone modified oligonucleotides have also been used in the development of several alternative strategies, which rely on altogether different mechanisms of action and show significant promise for therapeutic intervention. In this review the latest advances in the synthesis and evaluation of the most promising backbone modified oligos will be discussed, with a view to their future as novel pharmaceuticals. |
| Starting Page | 8 |
| Ending Page | 8 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.umist.ac.uk/departments/chemistry/about/staff/micklefield/cmc.pdf |
| PubMed reference number | 11472234v1 |
| Volume Number | 8 |
| Issue Number | 10 |
| Journal | Current medicinal chemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 2',5'-oligoadenylate Dosage Forms Nucleic Acids Oligonucleotides RNA Vertebral column antisense therapy aptamer invert sugar phosphodiester |
| Content Type | Text |
| Resource Type | Article |
