NDLI: Antisense oligonucleotides as therapeutic agents--is the bullet really magical?

Content Provider	Semantic Scholar
Author	Cheng, Yu Chin
Copyright Year	1993
Abstract	Because of the specificity of Watson-Crick base pairing, attempts are now being made to use oligodeoxynucleotides (oligos) in the therapy of human disease. However, for a successful outcome, the oligo must meet at least six criteria: (i) the oligos can be synthesized easily and in bulk; (ii) the oligos must be stable in vivo; (iii) the oligos must be able to enter the target cell; (iv) the oligos must be retained by the target cell; (v) the oligos must be able to interact with their cellular targets; and (vi) the oligos should not interact in a non-sequence-specific manner with other macromolecules. Phosphorothioate oligos are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria. The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://psych.colorado.edu/~campeaus/7215/Stein%20&%20Cheng%201993%20Science%20261%201004-1012.PDF
PubMed reference number	8351515v1
Volume Number	261
Issue Number	5124
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	2',5'-oligoadenylate Base Pairing Oligodeoxyribonucleotides Oligonucleotides Therapeutic agent (substance) Virus Replication macromolecule phosphorothioate
Content Type	Text
Resource Type	Article

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