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Bone marrow infarction in sickle cell anemia: correlation with hematologic profiles.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Milner, Paul F. A. Brown, Margaret |
| Copyright Year | 1982 |
| Abstract | Bone marrow infarction was investigated by 99mTc-sulfur colloid imaging in 42 patients with sickle cell anemia (SS) over a period of 2 yr. Marrow defects were demonstrated in 28 patients (66.6%), and in 15 (aged 19--52 yr), they were matched by roentgenographic evidence of medullary bone infarction. Repeated images showed no change in the size or site of these defects. Among 13 patients (aged 6--32 yr), all in crisis when initially examined, marrow defects were not associated with roentgenographic changes, and in many cases, repeated images showed resolution or decrease in size of the defects in 3--6 mo, even if the limb had been swollen and the marrow defect large. Among 14 patients (aged 18--36 yr), all asymptomatic at the time of study, no defects were found. Comparison of hematologic variables revealed a higher mean hemoglobin and hematocrit level among those with marrow infarcts (p less than 0.0001). High levels of HbF, or the presence of alpha-thalassemia, did not protect against marrow infarction. Pulmonary fat embolism was not observed. 99mTc-sulfur colloid marrow imaging was considered to provide more useful information in the initial management of bone pain and swelling in sickle cell crisis than either roentgenographs or conventional 99mTc-methyldiphosphate bone images. |
| File Format | PDF HTM / HTML |
| DOI | 10.1182/blood.V60.6.1411.bloodjournal6061411 |
| PubMed reference number | 7139126 |
| Journal | Medline |
| Volume Number | 60 |
| Issue Number | 6 |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/60/6/1411.full.pdf?sso-checked=true |
| Alternate Webpage(s) | https://doi.org/10.1182/blood.V60.6.1411.bloodjournal6061411 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
