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Bone marrow infarction in sickle cell anemia: correlation with hematologic profiles
| Content Provider | Scilit |
|---|---|
| Author | Milner, Pf Brown, M. |
| Copyright Year | 1982 |
| Description | Bone marrow infarction was investigated by 99mTc-sulfur colloid imaging in 42 patients with sickle cell anemia (SS) over a period of 2 yr. Marrow defects were demonstrated in 28 patients (66.6%), and in 15 (aged 19--52 yr), they were matched by roentgenographic evidence of medullary bone infarction. Repeated images showed no change in the size or site of these defects. Among 13 patients (aged 6--32 yr), all in crisis when initially examined, marrow defects were not associated with roentgenographic changes, and in many cases, repeated images showed resolution or decrease in size of the defects in 3--6 mo, even if the limb had been swollen and the marrow defect large. Among 14 patients (aged 18--36 yr), all asymptomatic at the time of study, no defects were found. Comparison of hematologic variables revealed a higher mean hemoglobin and hematocrit level among those with marrow infarcts (p less than 0.0001). High levels of HbF, or the presence of alpha- thalassemia, did not protect against marrow infarction. Pulmonary fat embolism was not observed. 99mTc-sulfur colloid marrow imaging was considered to provide more useful information in the initial management of bone pain and swelling in sickle cell crisis than either roentgenographs or conventional 99mTc-methyldiphosphate bone images. |
| Related Links | https://ashpublications.org/blood/article-pdf/60/6/1411/588478/1411.pdf |
| Ending Page | 1419 |
| Page Count | 9 |
| Starting Page | 1411 |
| DOI | 10.1182/blood.v60.6.1411.1411 |
| Journal | Blood |
| Issue Number | 6 |
| Volume Number | 60 |
| Language | English |
| Publisher | American Society of Hematology |
| Publisher Date | 1982-12-01 |
| Access Restriction | Open |
| Subject Keyword | Hematology Bone Marrow Anemia 99mtc Sulfur Colloid Marrow Infarction Journal: Blood (Vol- 87, Issue- 6) |
| Content Type | Text |
| Resource Type | Article |
