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Diagnostic Performance of Attenuation-Corrected Myocardial Perfusion Imaging for Coronary Artery Disease: A Systematic Review and Meta-Analysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Huang, Jei-Yie Huang, Chun-Kai Yen, R. F. Wu, Hon-Yen Tu, Yu-Kang Cheng, M. F. Lu, Ching-Chu Tzen, Kai-Yuan Chien, K. L. Wu, Yen-Wen |
| Copyright Year | 2016 |
| Abstract | Myocardial perfusion imaging (MPI) with SPECT is a well-established tool for the diagnosis of coronary artery disease (CAD). However, soft-tissue attenuation is a common artifact that limits the diagnostic accuracy of MPI. The aim of this study was to determine whether attenuation correction (AC) improved the diagnostic performance of MPI, using coronary angiography as a reference standard. METHODS MEDLINE and EMBASE were searched until March 2015 for studies evaluating AC MPI for the diagnosis of CAD. Methodologic quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. For each study, the sensitivity, specificity, and diagnostic odds ratio, along with 95% confidence intervals (CIs), were calculated to determine the diagnostic accuracy of AC versus non-attenuation-corrected (NAC) MPI. A bivariate mixed-effects model was applied for pooling the data. RESULTS Of 201 articles, 17 studies (1,701 patients) were identified, including 5 studies that used CT AC, 12 studies that used radionuclide source AC (RAC), and 15 studies that reported NAC results. The pooled sensitivities across studies were 0.80 (95% CI, 0.64-0.91), 0.85 (95% CI, 0.81-0.88), 0.84 (95% CI, 0.79-0.88), and 0.80 (95% CI, 0.75-0.85) for CT AC, RAC, all AC, and NAC, respectively. The pooled specificities were 0.83 (95% CI, 0.71-0.91), 0.81 (95% CI, 0.73-0.86), 0.80 (95% CI, 0.74-0.85), and 0.68 (95% CI, 0.61-0.74). Both sensitivities and specificities resulted in a pooled diagnostic odds ratio of 20 (95% CI, 12-34), 24 (95% CI, 13-43), 22 (95% CI, 13-35), and 9 (7-11). Significant differences in specificity and diagnostic odds ratios were noted when AC (including CT AC, RAC, and all AC) was compared with NAC. CONCLUSION The results from this study suggested that AC should be applied to MPI to improve the diagnosis of CAD, especially the specificity. |
| Starting Page | 1893 |
| Ending Page | 1898 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jnm.snmjournals.org/content/early/2016/07/21/jnumed.115.171462.full.pdf |
| PubMed reference number | 27445295v1 |
| Volume Number | 57 |
| Issue Number | 12 |
| Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Advertisements Arteriopathic disease Attenuation Correction Confidence Intervals Coronary Artery Disease Coronary angiography Gated Blood-Pool Imaging Myocardial Perfusion Imaging Odds Ratio Patients Pooled Sample Radioisotopes Reference Standards SLPI protein, human angiogram non-T, non-B, cALLa positive childhood acute lymphoblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
