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Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Park, Chul Yeon Oak-Kee Kim, Mee Kyoung Chung, Woo Baek Choi, Youn Seun Baek, K. Song, Ki-ho Kwon, H. -W. Wang, Hsueh Hwa |
| Copyright Year | 2015 |
| Abstract | Bone morphogenic protein 4 (BMP-4) is a known pro-inflammatory and pro-atherogenic cytokine. Here, we investigated whether the serum BMP-4 level predicts coronary artery disease (CAD) severity in humans. We measured serum BMP-4 concentrations in 1044 consecutive patients who underwent elective coronary angiography and percutaneous coronary intervention. CAD severity was estimated by the number of diseased vessels showing ≥ 50% diameter stenosis. Among males, the serum BMP-4 level was significantly lower in patients with multivessel disease (MVD) compared with those with single-vessel disease (SVD) (16.3 ± 22.6 vs. 22.0 ± 28.4 pg/mL, P < 0.01). After adjustment for other cardiovascular risk factors, a high serum BMP-4 level was an independent predictor for a decreased risk of MVD (odds ratio, 0.992; 95% confidence interval [CI], 0.985-0.998; P = .01) and patients in the lower tertile were 1.55-fold more likely to have MVD compared with upper tertile patients. Receiver-operating characteristic curve analysis demonstrated that the serum BMP-4 level had a 54% sensitivity and 54% specificity for predicting MVD (area under the curve [AUC], 56.5%; 95% CI, 51.9-61.0%; P < 0.01). Serum BMP-4 improved the predictive capability of risk factors for MVD (AUC with and without BMP-4: 64.9 and 63.6%, respectively). Considering the likelihood ratio and number of parameters, adding the serum BMP-4 level provided a better-fit model for predicting MVD compared with the model consisting of conventional risk factors (likelihood ratio χ2 = 6.20, P = .01). However, an association between serum BMP-4 and CAD was not observed in females.Serum BMP-4 levels are independently associated with CAD severity and contribute to discriminating CAD severity in males. |
| Starting Page | 868 |
| Ending Page | 874 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 26426615v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000001530 |
| DOI | 10.1097/md.0000000000001530 |
| Journal | Medicine |
| Volume Number | 94 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Area Under Curve Arteriopathic disease Blood Vessel Confidence Intervals Coronary Artery Disease Coronary angiography Diameter (qualifier value) Odds Ratio Patients Percutaneous Coronary Intervention Stenosis angiogram bone morphogenetic protein 4 cytokine likelihood ratio |
| Content Type | Text |
| Resource Type | Article |
