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Optically active trivalent phosphorus acid esters: synthesis, chirality at phosphorus and some transformations
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mikołajczyk, Maria |
| Copyright Year | 1980 |
| Abstract | Optically active trivalent phosphorus acid esters and thioesters have been obtained by three different methods: (a) asymmetric condensation of racemic trivalent phosphorus chlorides with achiral alcohols or thiols in the presence of optically active tertiary amines, (b) asymmetric reaction of racemic chlorophosphines with optically active alcohols (menthol), (c) stereospecific synthesis from optically active methylthio-alkoxy-phosphonium triflates. Chirality at phos phorus in and optical purity of the chiral trivalent phosphorus acid esters have been determined by chemical correlations. It has been demonstrated that nucleophilic substitution at chiral trivalent phosphorus occurs stereospecifically with inversion of configuration at phosphorus. A new synthesis of chiral tertiary phosphinés of high optical purity has also been devised. |
| Starting Page | 959 |
| Ending Page | 972 |
| Page Count | 14 |
| File Format | PDF HTM / HTML |
| DOI | 10.1351/pac198052040959 |
| Alternate Webpage(s) | http://iupac.org/publications/pac/pdf/1980/pdf/5204x0959.pdf |
| Alternate Webpage(s) | https://doi.org/10.1351/pac198052040959 |
| Volume Number | 52 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |