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Synthesis of Optically Active Oxazolines by an Organocatalytic Isocyanoacetate Aldol Reaction with α-Keto Esters
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Fei Chen, Jiean |
| Copyright Year | 2017 |
| Abstract | An enantioselective [3+2] cyclization is reported for the construction of a chiral oxazoline skeleton in moderate yield and up to 97% ee. The reactivity and stereochemical discrimination originate from the noncovalent interaction and orientation of a bifunctional catalyst. The novel combination of an α-keto ester and an α-isocyanoacetate establishes an oxazoline which could be a potential chiral ligand for metalmediated catalysis, and also could be easily converted into an optically active β-hydroxy-α-amino acid. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://web.pkusz.edu.cn/huang/files/2013/04/Synthesis-of-Optically-Active-Oxazolines-by-an-Organocatalytic-Isocyanoacetate-Aldol-Reaction-with-%CE%B1-Keto-Esters.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Carnitine esters:SCnt:Pt:Tiss:Qn Catalysis Chirality (chemistry) Cyclization Esters Ethinyl Estradiol Ligands NG-Nitroarginine Methyl Ester Optical rotation Thioctic Acid Topological skeleton |
| Content Type | Text |
| Resource Type | Article |
