Loading...
Please wait, while we are loading the content...
Similar Documents
Sexually differentiated actions of 3-PPP enantiomers on prolactin secretion
| Content Provider | Semantic Scholar |
|---|---|
| Author | Carlsson, Wictoria Eriksson, Elias Nilsson, Cecilia Carlsson, Arvid |
| Copyright Year | 1986 |
| Abstract | The ability of the enantiomers of the atypical dopamine receptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) to counteract gamma-butyrolactone-induced hyperprolactinemia was compared in male and female rats. Following gamma-butyrolactone (GBL) pretreatment serum prolactin concentrations were higher in female than in male rats. In males (-)-3-PPP tended to be somewhat less effective than (+)-3-PPP in decreasing serum prolactin concentrations (levels after (+)-3-PPP and (-)-3-PPP: 21% and 33%, respectively, of levels in GBL-pretreated control(s). In females the (-)-form induced a much weaker response than did the (+)-form (levels after (+)-3-PPP and (-)-3-PPP: 8% and 74%, respectively, of levels in GBL pretreated controls). Parallel experiments replacing GBL by reserpine yielded similar results. Data are discussed in terms of sex differences in responsiveness of pituitary dopamine receptors. |
| Starting Page | 951 |
| Ending Page | 954 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0028-3908(86)90028-6 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0028390886900286 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0028390886900286?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 3774120 |
| Alternate Webpage(s) | https://doi.org/10.1016/0028-3908%2886%2990028-6 |
| Journal | Medline |
| Volume Number | 25 |
| Journal | Neuropharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
