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Actions of angiotensin II and dopamine in the medial preoptic area on prolactin secretion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Leite, Cristiane Mota Machado, Giscard José Ribeiro Dornelles, Rita Cássia Menegati Franci, Celso Rodrigues |
| Copyright Year | 2008 |
| Abstract | Dopamine (DA) is known as a primary regulator of prolactin secretion (PRL) and angiotensin II (Ang II) has been recognized as one brain inhibitory factor of this secretion. In this work, estrogen-primed or unprimed ovariectomized rats were submitted to the microinjection of saline or Ang II after previous microinjection of saline or of DA antagonist (haloperidol, sulpiride or SCH) both in the medial preoptic area (MPOA). Our study of these interactions has shown that 1) estrogen-induced PRL secretion is mediated by Ang II and DA actions in the MPOA, i.e. very high plasma PRL would be prevented by inhibitory action of Ang II, while very low levels would be prevented in part by stimulatory action of DA through D(2) receptors, 2) the inhibitory action of Ang II depends on estrogen and is mediated in part by inhibitory action of DA through D(1) receptors and in other part by inhibition of stimulatory action of DA through D(2) receptors. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 17223721 |
| Journal | Medline |
| Volume Number | 57 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://www.biomed.cas.cz/physiolres/pdf/57/57_109.pdf |
| Alternate Webpage(s) | http://www.biomed.cas.cz/physiolres/pdf/prepress/878.pdf |
| Journal | Physiological research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
