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Magnetocardiography for the diagnosis of coronary artery disease: a systematic review and meta-analysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Agarwal, Rajender K. Saini, Abhimanyu Alyousef, Tareq Umscheid, Craig A. |
| Copyright Year | 2012 |
| Abstract | BACKGROUND Coronary artery disease (CAD) has a significant disease burden making early diagnosis and management imperative. Magnetocardiography (MCG) is a relatively new noninvasive technique that allows diagnosis of CAD by recording the magnetic fields generated by the electrical activity of the heart. METHODS We searched MEDLINE and the Cochrane Central Register of Controlled Trials for prospective studies that evaluated the test characteristics (e.g., sensitivity, specificity, likelihood ratios) of MCG for detection of CAD. Studies were included if they evaluated either patients with stable CAD documented by angiogram or patients presenting initially with acute coronary syndrome and subsequently diagnosed with CAD. The quality of included studies was assessed using an adaptation of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. We performed meta-analyses of sensitivity, specificity and positive and negative likelihood ratios using Meta-DiSc software. RESULTS Screening of titles and abstracts followed by full-text review yielded seven studies that met our inclusion criteria. Meta-analyses yielded a pooled sensitivity of 83% (95% confidence interval [CI] 80% to 86%) and a specificity of 77% (95% CI 73% to 81%). The pooled positive likelihood ratio was 3.92 (95% CI 2.30 to 6.66) and negative likelihood ratio was 0.20 (95% CI 0.12 to 0.35). Significant heterogeneity was present in all meta-analyses. CONCLUSIONS The pooled test characteristics for MCG are similar to those of existing noninvasive modalities for diagnosing CAD. Our results suggest that MCG is a potential complementary or alternative tool for noninvasive detection of CAD. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1542-474X.2012.00538.x |
| PubMed reference number | 23094875 |
| Journal | Medline |
| Volume Number | 17 |
| Issue Number | 4 |
| Alternate Webpage(s) | http://www.crd.york.ac.uk/CRDWeb/PrintPDF.php?AccessionNumber=12012052993&Copyright=Database+of+Abstracts+of+Reviews+of+Effects+(DARE)%3Cbr+/%3EProduced+by+the+Centre+for+Reviews+and+Dissemination+%3Cbr+/%3ECopyright+%26copy%3B+2019+University+of+York%3Cbr+/%3E |
| Alternate Webpage(s) | https://www.crd.york.ac.uk/CRDWeb/PrintPDF.php?AccessionNumber=12012052993&Copyright=Database+of+Abstracts+of+Reviews+of+Effects+(DARE)%3Cbr+/%3EProduced+by+the+Centre+for+Reviews+and+Dissemination+%3Cbr+/%3ECopyright+%26copy%3B+2019+University+of+York%3Cbr+/%3E |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1542-474X.2012.00538.x |
| Journal | Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
