Association Between Parkinson's Disease and Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Content Provider	Europe PMC
Author	Chua, Shaun Kai Kiat Saffari, Seyed Ehsan Lee, Selene Joon Yan Tan, Eng-King
Copyright Year	2022
Abstract	Background:The relationship between Parkinson’s disease (PD) and coronary artery disease (CAD) is unclear.Objective:This study aims to investigate whether PD and CAD are associated through systematic review and meta-analysis of observational studies.Methods:Electronic database search of PubMed, EMBASE, and Web of Science for observational studies published from 1 January 2010 to 1 August 2021 was conducted using terms related to PD and CAD. Unadjusted risk ratios (RR) and odds ratios (OR) of included cohort and case-control studies respectively were used to ascertain the association between PD and CAD. Study heterogeneity was evaluated using the I2 test.Results:Forty-one full-text studies were initially retrieved for eligibility assessment. Five studies that satisfied the inclusion criteria, consisting of three cohort and two case-control studies, were eventually included in this meta-analysis. The five studies enrolled 35,237 PD patients and 650,866 non-PD patients. PD and CAD were found to be significantly associated in cohort studies (RR = 2.23, 95% CI = 1.08–4.59, p = 0.03; Fig. 2), which held after sensitivity analysis (RR = 1.45, 95% CI = 1.31–1.60, p < 0.001; Fig. 3). Case-control studies found a trend towards association of PD and CAD approaching significance (OR = 1.47, 95% CI = 0.84–2.56, p = 0.18; Fig. 2).Conclusion:Overall, this meta-analysis suggests that PD is associated with CAD. The underlying mechanisms, as well as the role of ethnicity and other comorbidities on the relationship between PD and CAD should be further explored.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC9789484&blobtype=pdf
ISSN	18777171
Journal	Journal of Parkinson's Disease [J Parkinsons Dis]
Volume Number	12
PubMed Central reference number	PMC9789484
Issue Number	6
PubMed reference number	35694936
e-ISSN	1877718X
DOI	10.3233/jpd-223291
Language	English
Publisher	IOS Press
Publisher Date	2022-01-01
Publisher Place	Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands
Access Restriction	Open
Rights License	This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2022 – The authors. Published by IOS Press
Subject Keyword	Coronary artery disease meta-analysis observational studies Parkinson’s disease systematic review
Content Type	Text
Resource Type	Article
Subject	Neurology (clinical) Cellular and Molecular Neuroscience