NDLI: Angiotensin II as an Inducer of Atherosclerosis : Evidence from Mouse Studies

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Angiotensin II as an Inducer of Atherosclerosis : Evidence from Mouse Studies

Content Provider	Semantic Scholar
Author	Pellegrin, Maxime
Copyright Year	2013
Abstract	Atherosclerosis (ATS) is a chronic inflammatory disease characterized by formation of a plaque or lesion (also called atheroma) in the intimal layer of the arterial wall. Atherosclerotic plaque is composed of oxidized lipids and lipoproteins, inflammatory cell infiltrates, areas of cell death and fibrosis [1]. ATS is the leading cause of morbidity and mortality in developed nations. ATS is a dynamic disease evolving in time often-taking decades to develop advanced lesions responsible for clinical symptoms. Plaques may remain asymptomatic (subclinical disease), become occlusive (intermittent claudication or stable angina pectoris), or become thrombosis-prone (vulnerable) leading to athero-thrombotic events, such as myocardial infarction or stroke [2]. Pathogenesis of ATS is not yet fully elucidated; however clear evidence indicate that the Renin-Angiotensin System (RAS), and in particular its final product Angiotensin (Ang) II, play a pivotal role in atherogenesis.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://serval.unil.ch/resource/serval:BIB_E6568726F216.P001/REF
Language	English
Access Restriction	Open
Subject Keyword	Angina Pectoris Angiotensin II Angiotensins Atherosclerosis CNS disorder Cell Death Cerebrovascular accident Cessation of life Dental Plaque Fibrosis Infiltration Intermittent Claudication Lipoproteins Morbidity - disease rate Myocardial Infarction Senile Plaques Thrombosis inflammatory disease
Content Type	Text
Resource Type	Article

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