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Mild and selective palladium-catalyzed dimerization of terminal alkynes to form symmetrical (Z,Z)-1,4-dihalo-1,3-dienes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Li, Jin-Heng Liang, Yun Xie, Ye-Xiang |
| Copyright Year | 2004 |
| Abstract | A regioselective and stereoselective palladium-catalyzed dimerization of terminal alkynes method for the synthesis of symmetrical (Z,Z)-1,4-dihalo-1,3-dienes is presented. In the presence of a catalytic amount of PdX(2) and 3 equiv of CuX(2) (X = Cl and Br), terminal alkynes were dimerized to afford (Z,Z)-1,4-dihalo-1,3-dienes in good yields. The results showed that the effect of solvent had a fundamental influence on the chemoselectivity of the dimerization reaction. The mechanism of the palladium-catalyzed dimerization reaction is also discussed. |
| File Format | PDF HTM / HTML |
| DOI | 10.1021/jo0486645 |
| PubMed reference number | 15527303 |
| Journal | Medline |
| Volume Number | 69 |
| Issue Number | 23 |
| Alternate Webpage(s) | http://hgxy.hunnu.edu.cn/UploadFile/20061116103452753.pdf |
| Alternate Webpage(s) | https://doi.org/10.1021/jo0486645 |
| Journal | The Journal of organic chemistry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |