Loading...
Please wait, while we are loading the content...
Similar Documents
Association of plasma fibrinogen and plasminogen with prognosis of inoperable chronic thromboembolic pulmonary hypertension.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kato, Fumiaki Tanabe, Nobuhiro Urushibara, Takashi Kasai, Hajime Takeuchi, Takao Sekine, Ayumi Suda, Rika Nishimura, Rintaro Jujo, Takayuki Sugiura, Toshihiko Shigeta, Ayako Sakao, Seiichiro Kasahara, Yasunori Tatsumi, Koichiro |
| Copyright Year | 2014 |
| Abstract | BACKGROUND It is unclear whether abnormalities of coagulation or fibrinolysis are associated with disease progression of chronic thromboembolic pulmonary hypertension (CTEPH). The aim of this study was to investigate the association of these factors with the severity and prognosis of CTEPH. METHODS AND RESULTS Between 1986 and 2011, plasma fibrinogen and plasminogen were measured in 89 of 106 consecutive patients with inoperable CTEPH (17 men; mean age, 55.9±14.1 years old; mean pulmonary arterial pressure, 44.0±12.4 mmHg) and the association of level with severity and prognosis were also examined. Seventeen patients had high fibrinogen and low plasminogen (medians, ≥291 mg/dl and <101%, respectively). These patients had significantly lower cardiac index (2.26±0.68 vs. 2.70±0.57 L·min(-1)·m(-2), P=0.007), higher pulmonary vascular resistance (PVR; 13.29±7.54 vs. 9.15±4.14 Wood units, P=0.003), and poor survival (5-year survival, 35.3% vs. 88.0%, P<0.001) compared to the other 72 patients. Additional analysis showed significantly poor survival in these patients compared with the other patients who did not have modern therapy. On multivariate analysis plasma fibrinogen, plasminogen and PVR were independent predictors of survival in medically treated patients. CONCLUSIONS High plasma fibrinogen and low plasminogen are associated with poor survival in CTEPH patients without modern therapy. |
| Starting Page | 1405 |
| Ending Page | 1414 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/circj/78/7/78_CJ-13-1535/_pdf |
| PubMed reference number | 24909805v1 |
| Volume Number | 78 |
| Issue Number | 7 |
| Journal | Circulation journal : official journal of the Japanese Circulation Society |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 101 Mouse Chronic thromboembolic pulmonary hypertension Congenital Abnormality Disease Progression Eighty Nine Forecast of outcome Hypertensive disease Patients fibrinogen complex location mg/dl |
| Content Type | Text |
| Resource Type | Article |
