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In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Goodridge, Helen S. Marshall, Fraser A. Wilson, Emma H. Houston, Katrina M. Liew, Foo Yew Eddy Harnett, Margaret M. Harnett, William |
| Copyright Year | 2004 |
| Abstract | We have previously shown in an in vitro study that the filarial nematode phosphorylcholine (PC)-containing glycoprotein ES-62 promotes a murine dendritic cell (DC) phenotype that induces T helper type 2 (Th2) responses. We now show that, in addition to directly priming Th2 responses, ES-62 can act to dampen down the pro-inflammatory DC responses elicited by lipopolysaccharide. Furthermore, we also demonstrate that murine DCs and macrophages derived ex vivo from bone marrow cells exposed in vivo to ES-62 by release from osmotic pumps are hyporesponsive to subsequent stimulation with lipopolysaccharide. These effects can be largely mimicked by exposure to the PC moiety of ES-62 conjugated to an irrelevant protein. The data we provide are, as far as we aware, the first to show that a defined pathogen product can modulate the developmental pathway of bone marrow cells of the immune system in vivo. Such a finding could have important implications for the use of pathogen products or their derivatives for immunotherapy. |
| File Format | PDF HTM / HTML |
| DOI | 10.1111/j.1365-2567.2004.01993.x |
| PubMed reference number | 15554927 |
| Journal | Medline |
| Volume Number | 113 |
| Issue Number | 4 |
| Alternate Webpage(s) | https://eurekamag.com/pdf/004/004198911.pdf |
| Alternate Webpage(s) | https://doi.org/10.1111/j.1365-2567.2004.01993.x |
| Journal | Immunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
