NDLI: A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells

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A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells

Content Provider	Scilit
Author	Whelan, Michael Harnett, Margaret M. Houston, Katrina M. Patel, Vanshree Harnett, William Rigley, Kevin P.
Copyright Year	2000
Description	Although exogeneous “danger” signals such as LPS can activate APC to produce a Th1 response, the nature of events initiating a Th2 response is controversial. We now show that pathogen-derived products have the capacity to induce bone marrow-derived dendritic cell cultures to acquire a phenotype that promotes the differentiation of naive $CD4^{+}$ T cells toward either a Th1 or Th2 phenotype. Thus, LPS-matured dendritic cells (DC1) promote a Th1 response (increased generation of IFN-γ and reduced production of IL-4) by Ag-stimulated $CD4^{+}$ T cells from the DO.11.10 transgenic mouse expressing a TCR specific for an OVA peptide (OVA323–339). In contrast, a phosphorylcholine-containing glycoprotein, ES-62, secreted by the filarial nematode, Acanthocheilonema viteae, which generates a Th2 Ab response in vivo, is found to induce the maturation of dendritic cells (DC2) with the capacity to induce Th2 responses (increased IL-4 and decreased IFN-γ). In addition, we show that the switch to either Th1 or Th2 responses is not effected by differential regulation through CD80 or CD86 and that a Th2 response is achieved in the presence of IL-12.
Ending Page	6460
Page Count	8
Starting Page	6453
ISSN	00221767
e-ISSN	15506606
DOI	10.4049/jimmunol.164.12.6453
Alternate Webpage(s)	http://www.jimmunol.org/content/164/12/6453.full.pdf
Journal	The Journal of Immunology
Issue Number	12
Volume Number	164
Language	English
Publisher	The American Association of Immunologists
Publisher Date	2000-06-15
Access Restriction	Open
Subject Keyword	Bone Marrow Cell Cultures Dendritic Cells
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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