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Sclerostin is a possible candidate marker of arterial stiffness: Results from a cohort study in Catania.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gaudio, Agostino Fiore, V. De S. Rapisarda, Rosario Sidoti, Maria Helga Xourafa, Anastasia Catalano, Antonino Tringali, Giovanni Zanoli, Luca Signorelli, Salvatore Santo Fiore, Carmelo Erio |
| Copyright Year | 2017 |
| Abstract | Osteoporosis and cardiovascular disease are worldwide public health issues. Recent evidence indicates a possible role of the canonical Wnt/β-catenin signalling pathway as a common mediator between these two diseases. The aim of the present study was to investigate the relationship between serum concentrations of sclerostin and Dkk1, two extracellular inhibitors of Wnt/β-catenin signalling, with carotid intima-media thickness (CIMT) and with arterial stiffness, evaluated by measuring the pulse wave velocity (PWV) in an ambulatory population of adults. To this aim, 67 subjects were recruited in the 'Atherosclerosis and osteoporosis: identification of common pathogenetic factors' investigation. Serum sclerostin levels correlated positively with CIMT (r=0.314, p=0.03) and inversely with the augmentation index, a marker of arterial stiffness (r=-0.286, p<0.05), whereas Dkk1 did not. Moreover, in a multivariate linear regression model, sclerostin [β -0.1472; p=0.0023; standard error (SE)=0.04620] was an independent predictor of PWV in the study subjects. Our study shows that, following adjustment for confounders, sclerostin is an independent predictor of arterial stiffness in an ambulatory population, whereas Dkk1 is not. |
| Starting Page | 3420 |
| Ending Page | 3424 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/mmr/15/5/3420/download |
| PubMed reference number | 28339088v1 |
| Alternate Webpage(s) | https://doi.org/10.3892/mmr.2017.6390 |
| DOI | 10.3892/mmr.2017.6390 |
| Journal | Molecular medicine reports |
| Volume Number | 15 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Arterial Stiffness Atherosclerosis Cardiovascular Diseases Carotid Artery Diseases Linear IgA Bullous Dermatosis Mediator brand of benfluorex hydrochloride Osteoporosis Pulse Wave Velocity SOST gene Signal Transduction Standard Error biological signaling |
| Content Type | Text |
| Resource Type | Article |
