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Phenotype and function of human T lymphocyte subsets: consensus and issues.

Content Provider	Semantic Scholar
Author	Appay, Victor Lier, René A. W. Van Sallusto, Federica Roederer, Mario
Copyright Year	2008
Abstract	In recent years, a tremendous effort has been devoted to the detailed characterization of the phenotype and function of distinct T cell subpopulations in humans, as well as to their pathway(s) of differentiation and role in immune responses. But these studies seem to have generated more questions than definitive answers. To clarify issues related to the function and differentiation of T cell subsets, one session of the MASIR 2008 conference was dedicated to this topic. Several points of consensus and discord were highlighted in the work presented during this session. We provide here an account of these points, including the relative heterogeneity of T cell subpopulations during infections with distinct pathogens, the relationship between phenotypic and functional T cell attributes, and the pathway(s) of T cell differentiation. Finally, we discuss the problems which still limit general agreement.
Starting Page	586
Ending Page	593
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cytobase.montp.inserm.fr/ftp/Biblio/Phenotype%20and%20function%20of%20human%20T%20lymphocyte%20Subsets%20consensus%20and%20issues.pdf
PubMed reference number	18785267v1
Alternate Webpage(s)	https://doi.org/10.1002/cyto.a.20643
DOI	10.1002/cyto.a.20643
Journal	Cytometry. Part A : the journal of the International Society for Analytical Cytology
Volume Number	73
Issue Number	11
Language	English
Access Restriction	Open
Subject Keyword	Cellular Phone Chronic Lymphocytic Leukemia Immune response Infection Lymphocyte Subset T-Lymphocyte childhood lymphocyte depletion Hodgkin's lymphoma
Content Type	Text
Resource Type	Article

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