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Characterization of a novel Na+-independent amino acid transporter in horse erythrocytes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fincham, Daron A. Mason, D. L. Young, James D. |
| Copyright Year | 1985 |
| Abstract | Horse erythrocytes are polymorphic with respect to L-alanine permeability. The present investigation compared the specificity, kinetics and cation-dependence of erythrocyte amino acid transport in two groups of thoroughbred horses, those with erythrocyte L-alanine permeabilities in the range 5-15 mumol/h per litre of cells (0.2 mM extracellular L-alanine, 37 degrees C) (transport-negative type) and those with L-alanine permeabilities in the range 450-700 mumol/h per litre of cells (transport-positive type). Transport-positive cells are shown to possess a novel high-affinity, stereospecific, Na+-independent transporter selective for neutral amino acids of intermediate size. This carrier system (provisional designation asc) operates preferentially in an exchange mode and is functionally absent from erythrocytes of transport-negative-type horses. |
| Starting Page | 13 |
| Ending Page | 20 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemj.org/content/ppbiochemj/227/1/13.full.pdf |
| PubMed reference number | 3994678v1 |
| Volume Number | 227 |
| Issue Number | 1 |
| Journal | The Biochemical journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Transaminase Amino Acid Transporter Amino Acids Amino Acids, Neutral Cations Erythrocytes Identifier Permeability Thioctic Acid amino acid transport |
| Content Type | Text |
| Resource Type | Article |
