NDLI: Transient receptor potential channels regulate myogenic tone of resistance arteries.

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Transient receptor potential channels regulate myogenic tone of resistance arteries.

Content Provider	Semantic Scholar
Author	Welsh, Donald G. Morielli, Anthony D. Nelson, Mark T. Brayden, Joseph E.
Copyright Year	2002
Abstract	Elevation of intravascular pressure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and this response is a key element in blood flow regulation. However, the nature of pressure-induced depolarization has remained elusive. In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure. Antisense oligodeoxynucleotides to TRPC6 decreased TRPC6 protein expression and greatly attenuated arterial smooth muscle depolarization and constriction caused by elevated pressure in intact cerebral arteries. Suppressing the expression of this channel protein also reduced the current density of a major cation current in resistance artery smooth muscle cells. We propose that TRPC6 channels play an essential role in regulation of myogenic tone.
Starting Page	1
Ending Page	3
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circres.ahajournals.org/content/circresaha/90/3/248.full.pdf?download=true
PubMed reference number	11861411v1
Volume Number	90
Issue Number	3
Journal	Circulation research
Language	English
Access Restriction	Open
Subject Keyword	Arterial system Arteries Artery Smooth Muscle Tissue Cations Homologous Gene Muscle Cells Myocytes, Smooth Muscle Oligodeoxyribonucleotides Smooth muscle (tissue) Structure of arteriole Structure of cerebral artery TRPC6 gene protein expression
Content Type	Text
Resource Type	Article

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