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In vivo modulation of the activity of pyramidal neurons in the rat medial prefrontal cortex by 5-HT2A receptors: relationship to thalamocortical afferents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Puig, Marta Celada, Pau Díaz-Mataix, Llorenç Artigas, Francesc |
| Copyright Year | 2003 |
| Abstract | The activation of 5-HT(2A) receptors in medial prefrontal cortex (mPFC) by the hallucinogen DOI increases the firing activity of dorsal raphe (DR) 5-HT neurons and prefrontal 5-HT release. Here we show that the i.v. administration of DOI markedly affected the firing rate of identified pyramidal neurons recorded extracellularly. DOI excited (481%) 21/56 neurons, inhibited (11%) 17/56 neurons and left the rest unaffected (overall 2.4-fold increase in firing rate). Both effects were antagonized by 5-HT(2A) receptor blockade. 5-HT(2A)-mediated orthodromic excitations were recorded in pyramidal neurons projecting to DR after electrical stimulation of this nucleus. We also examined whether the effects of DOI in mPFC involve thalamic excitatory inputs. The disinhibition of the mediodorsal and centromedial nuclei of the thalamus by local bicuculline resembled the effects of DOI as it increased pyramidal cell firing and 5-HT release in mPFC. However, the selective activation of prefrontal micro -opioid and mGlu II receptors counteracted the effects of the thalamic disinhibition but not those of DOI. Moreover, extensive thalamic lesions did not alter the effect of DOI on pyramidal cell firing and 5-HT release. We conclude that DOI increases the activity of the mPFC-DR circuit by an action on postsynaptic 5-HT(2A) receptors unrelated to thalamocortical afferents. |
| Starting Page | 1496 |
| Ending Page | 1501 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://watermark.silverchair.com/1300870.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAagwggGkBgkqhkiG9w0BBwagggGVMIIBkQIBADCCAYoGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM4qIe968PyoqEIGaDAgEQgIIBW7tIQy7rKBDuMU73BgARjTabfnnaFuFABxphLd4PFvrI72s0uHX3aCEOjQwfYSWceapBAHcOPwPSX-tKsDS0Tt3Gso24iQP2fplaR3E6xaQMriOczG6f4OwcyK3dcL7Is7VVOM9sfmHO3P_tHrgIRRD9lPQS_jXQbRTOsgKOMVnRBIQoQYiYUfRwza3p2Dy6y0rPeY53yp4L1ySH_3u3roM9SjQ-JBG67FKP_M2NVSZfKcYVDROOHChd3phceaBVLY0D2YxyQ03JXd0tTEBD_tgFDo--QLRJ7u2Du8Wv81L-bNVzW0nGV5Lo-AvxQJLR5NMi45y9p4uDXHxujlNugd1rX7WYHwKvvvHwG5HhoqGpvpbsGITzzEiMyC7oDGqk5APGt83FnIuDiCx5PfrcbasZivW244RUe4X_-XWtnqTV-5Heyj30gpz5DcmIlGQj1lcRu_aX2ue4W53p |
| PubMed reference number | 12853374v1 |
| Volume Number | 13 |
| Issue Number | 8 |
| Journal | Cerebral cortex |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bicuculline Cell Nucleus Digital Object Identifier Electric stimulation technique Hallucinogens Neurons Prefrontal Cortex Pyramidal Cells Pyramidal cell of cerebral cortex Receptor, Serotonin, 5-HT2A Serotonin Social disinhibition Thalamic structure dorsal raphe nucleus raphe nuclei |
| Content Type | Text |
| Resource Type | Article |
