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Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Amargós-Bosch, Mercè Adell, Albert Artigas, Francesc Casañas |
| Copyright Year | 2007 |
| Abstract | The prefrontal cortex (PFC) is involved in the pathophysiology of schizophrenia. PFC neuronal activity is modulated by monoaminergic receptors for which antipsychotic drugs display moderate-high affinity, such as 5-HT(2A) and alpha(1)-adrenoceptors. Conversely, PFC pyramidal neurons project to and modulate the activity of raphe serotonergic neurons and serotonin (5-HT) release. Under the working hypothesis that atypical antipsychotic drugs may partly exert their action in PFC, we assessed their action on the in vivo 5-HT release evoked by increasing glutamatergic transmission in rat medial PFC (mPFC). This was achieved by applying S-AMPA in mPFC (reverse dialysis) or by disinhibiting thalamic excitatory afferents to mPFC with bicuculline. The application of haloperidol, chlorpromazine, clozapine and olanzapine in mPFC by reverse dialysis (but not reboxetine or diazepam) reversed the S-AMPA-evoked local 5-HT release. Likewise, the local (in mPFC) or systemic administration of these antipsychotic drugs reversed the increased prefrontal 5-HT release produced by thalamic disinhibition. These effects were shared by the 5-HT(2A) receptor antagonist M100907 and the alpha(1)-adrenoceptor antagonist prazosin. However, raclopride (DA D2 antagonist) had very modest effects. These results suggest that, besides their action in limbic striatum, antipsychotic drugs may attenuate glutamatergic transmission in PFC, possibly by interacting with 5-HT(2A) and/or alpha(1)-adrenoceptors. |
| Starting Page | 292 |
| Ending Page | 299 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://diposit.ub.edu/dspace/bitstream/2445/36007/9/04.MAB_TREBALLS_TREBALL_5.pdf |
| Alternate Webpage(s) | http://tdx.cat/bitstream/handle/10803/870/04.MAB_TREBALLS_TREBALL_5.pdf?sequence=9 |
| Alternate Webpage(s) | http://www.tesisenred.net/bitstream/handle/10803/870/04.MAB_TREBALLS_TREBALL_5.pdf?sequence=9 |
| PubMed reference number | 17394545v1 |
| Volume Number | 102 |
| Issue Number | 2 |
| Journal | Journal of neurochemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AMPA Receptors Antipsychotic Agents Appetite Depressants Bicuculline CFP wt Allele Chlorpromazine Clozapine Diazepam Dopamine Haloperidol MDL 100907 Neostriatum Prazosin Prefrontal Cortex Pyramidal Cells Raclopride Receptor, Serotonin, 5-HT2A Schizophrenia Serotonergic Neurons Serotonin Social disinhibition Thalamic structure olanzapine physical hard work raphe nuclei reboxetine |
| Content Type | Text |
| Resource Type | Article |
