Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2

Content Provider	Scilit
Author	Urosevic, Mirjana Kamarashev, Jivko Burg, Günter Dummer, Reinhard Chen, Eleanor Hermanson, Spencer Ekker, Stephen C.
Copyright Year	2004
Description	Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas, are rare entities that have only been recently recognized and characterized. These lymphomas often show an aggressive clinical course. We investigated the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in 3 CD56+CD4+ and 4 CD8+ cutaneous T-cell lymphomas. HLA-G expression was detected in 2 of 3 lymphomas of the CD56+CD4+ type and in all lymphomas of CD8+ type. It is of note that CD56+CD4+ lymphomas displayed stronger HLA-G reactivity. The expression of IL-10 matched the expression of HLA-G. Together with the expression of IL-10, HLA-G might be one of the factors accounting for the evasion of immunosurveillance, thus contributing to aggressive phenotype of these lymphoma entities.
Related Links	http://bloodjournal.hematologylibrary.org/content/103/5/1710.full.pdf
Ending Page	1798
Page Count	3
Starting Page	1796
DOI	10.1182/blood-2003-10-3372
Journal	Blood
Issue Number	5
Volume Number	103
Language	English
Publisher	American Society of Hematology
Publisher Date	2004-03-01
Access Restriction	Open
Subject Keyword	Dermatology Hematology Zebrafish Angiogenesis Syndecan Expression Patterns Angiogenic Sprouting Vegf Signaling Proteoglycan Embryos Journal: Blood (Vol- 84, Issue- 5)
Content Type	Text
Resource Type	Article