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The relationship of calbindin-containing neurons with substance P, Leu-enkephalin and cholecystokinin fibres: An immunohistochemical study in the rat thalamus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Battaglia, Giorgio Stefano Colacitti, Claudia Bentivoglio, Marina |
| Copyright Year | 1992 |
| Abstract | In the rat thalamus, immunoreactivity for the calcium binding protein calbindin (Cb) is mostly confined to neuronal cell bodies, sometimes revealing proximal dendrites, of the midline, intralaminar and posterior regions. Substance P (SP)-, cholecystokinin (CCK)- and Leu-enkephalin (L-ENK)-immunoreactive (ir) elements in the thalamus are fibre-like structures, intermingled with punctate elements probably representing axonal arborizations and their synaptic boutons. These peptidergic fibres are unevenly distributed in several thalamic domains, including the areas that contain Cb-ir neurons. The relationship between Cb-ir cell bodies and these three different peptidergic systems of thalamic innervation was studied with immunohistochemistry. Single-labelling experiments on adjacent sections and double immunostaining on the same section were performed. A considerable overlap between Cb-ir perikarya and SP-ir fibres was found in most thalamic nuclei. In particular, in the intralaminar nuclei and posterior complex, SP-ir punctate elements were frequently observed in close proximity to Cb-ir cell bodies and dendrites. On the other hand, no consistent topographical correspondence between Cb-ir perikarya and CCK- or L-ENK-ir fibres was evident. Altogether, the present data suggest a selective anatomical and, possibly, functional relationship between SP and Cb in at least a subpopulation of rat thalamic neurons. |
| Starting Page | 453 |
| Ending Page | 464 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0891-0618(92)90002-8 |
| PubMed reference number | 1282325 |
| Journal | Medline |
| Volume Number | 5 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0891061892900028 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0891061892900028?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0891-0618%2892%2990002-8 |
| Journal | Journal of Chemical Neuroanatomy |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
