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Immunohistochemical evidence for separate populations of somatostatin-containing and substance P-containing primary afferent neurons in the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hökfelt, Tomas G. M. Elde, Robert Johansson, Olle E. Luft, Rolf Arimura, Akira |
| Copyright Year | 1976 |
| Abstract | Abstract The localization of two small peptides, somatostatin and substance P, has been studied with the indirect immunofluorescence technique. Both peptides were present in small neuronal cell bodies in spinal ganglia, in fibers in the dorsal horn of the spinal cord and in fibers in the intestinal wall. By comparing consecutive sections incubated with antisera to somastostatin and to substance P respectively, it was established that somatostatin, or somatostatin-like immunoreactivity and substance P, or substance P-like immunoreactivity are present in different cells. This is possibly indicated also by a somewhat differential distribution of the immunoreactive fibers in the dorsal horn: the highest concentration of somatostatin-positive fibers was observed in lamina II, whereas abundant substance P-positive fibers were present also in lamina I. Furthermore, numerous substance P-, but no somatostatin-positive fibers, were found around the central canal and in the ventral horns. In the intestinal wall more substance P-positive than somatostatin-positive fibers were seen. The present results indicate that two subpopulations of primary sensory neurons exist, one containing somatostatin, or somatostatin-like immunoreactivity, and the other containing substance P, or substance P-like immunoreactivity. |
| Starting Page | 331 |
| Ending Page | 343 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0306-4522(76)90008-7 |
| PubMed reference number | 1004708 |
| Journal | Medline |
| Volume Number | 1 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0306452276900087 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0306452276900087?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0306-4522%2876%2990008-7 |
| Journal | Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
