NDLI: Suppression of androgen production by D-tryptophan-6-luteinizing hormone-releasing hormone in man.

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Suppression of androgen production by D-tryptophan-6-luteinizing hormone-releasing hormone in man.

Content Provider	Semantic Scholar
Author	Tolis, George Mehta, Aa Comaru-Schally, Ana Maria Schally, Andrew V.
Copyright Year	1981
Abstract	Four male transsexual subjects were given a superactive luteinizing hormone-releasing hormone (LHRH) analogue, D-tryptophan-6-LHRH at daily doses of 100 micrograms for 3--6 mo. A decrease in beard growth, acne, and erectile potency was noted; the latter was documented objectively with the recordings of nocturnal penile tumescence episodes. Plasma testosterone and dihydrotestosterone levels fell to castrate values; basal prolactin and luteinizing hormone levels showed a small decline, whereas the acutely releasable luteinizing hormone was significantly suppressed. A rise of plasma testosterone from castrate to normal levels was demonstrable with the use of human chorionic gonadotropin. Discontinuation of treatment led to a normalization of erectile potency and plasma testosterone. The suppression of Leydig cell function by D-tryptophan-6-LHRH might have wide application in reproductive biology and in endocrine-dependent neoplasia (where it could replace surgical castration).
File Format	PDF HTM / HTML
DOI	10.1172/JCI110320
PubMed reference number	6456277
Journal	Medline
Volume Number	68
Issue Number	3
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/110000/110320/JCI81110320.pdf
Alternate Webpage(s)	http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC370866&blobtype=pdf
Alternate Webpage(s)	https://doi.org/10.1172/JCI110320
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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