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On the Role of Tryptophan in Luteinizing-Hormone-Releasing Hormone (Luliberin)
| Content Provider | Scilit |
|---|---|
| Author | Hazum, Eli Fridkin, Mati Meidan, Rina Koch, Yitschak |
| Copyright Year | 1977 |
| Description | Journal: Journal of Biological Inorganic Chemistry The tryptophan residue of luteinizing-hormone-releasing hormone (luliberin) was chemically modified to produce the following analogs: [Trp(o)3]luliberin, Trp-(2,4-dinitrophenylsulfenyl)-luliberin, Trp-(2-hydroxy-5-nitrobenzyl)luliberin, (Trp-S-luliberin)2, Trp-CH3S-luliberin and Trp-formyl-luliberin. The luteinizing-hormone-releasing activity of those analogs was determined by bioassay in vitro and found to be 0.2%, 0.2%, 0.6%, 1.5%, 1.7% and 7% of that of the natural hormone, respectively. These results demonstrate that alterations in the indole moiety of tryptophan-3, which lead to a reduction in its electron density or sterically restrict its electron avaliability, are associated with a dramatic loss of biological activity. |
| Related Links | http://onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1977.tb11806.x/pdf |
| Ending Page | 273 |
| Page Count | 5 |
| Starting Page | 269 |
| ISSN | 09498257 |
| e-ISSN | 14321327 |
| DOI | 10.1111/j.1432-1033.1977.tb11806.x |
| Journal | Journal of Biological Inorganic Chemistry |
| Issue Number | 1 |
| Volume Number | 79 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 1977-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biological Inorganic Chemistry Endocrinology and Metabolism Releasing Hormone Luteinizing Hormone Releasing Role of Tryptophan Tryptophan in Luteinizing |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry Inorganic Chemistry |
