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Determination of polycyclic aromatic hydrocarbons in the lung.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Seto, Haruo Ohkubo, Tadashi Kanoh, Tadashi Koike, Masahiro Nakamura, Kazuo Kawahara, Yoshito |
| Copyright Year | 1993 |
| Abstract | Polycyclic aromatic hydrocarbons (PAHs) accumulated in human lung samples from men (n = 236) and women (n = 128) were determined by high-performance liquid chromatography (HPLC) to examine their association with lung cancer. The mean values for benzo[a]pyrene (BaP), benzo[k]fluoranthene (BkF), and benzo[g,h,i]perylene (BghiP) in lungs (ng/g dry lung) of Japanese autopsied patients were 0.54, 0.44, and 0.87, respectively. The modal values were 0.3, 0.3 and 0.5, respectively. Each of the PAH concentrations was highly correlated with the others (r > 0.83). PAH concentrations in the lungs showed age-related increases with low correlation-coefficient values. BaP, BkF and BghiP concentrations in lungs of various subgroups were in the following order: male > female; and lung cancer > all cancers > non-cancer among male not female group. Only BghiP concentration in the lungs of the male smoker group is significantly higher (P < 0.10) than that of the male non-smoker group. Even among non-smoker groups, PAH concentrations in the lungs of male group were significantly higher than those of female group. In the male population, excess exposure to PAHs together with fine carbon particles, such as tobacco smoke or diesel exhaust, correlated with increased prevalence of lung cancer. |
| Starting Page | 498 |
| Ending Page | 503 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/BF01146169 |
| PubMed reference number | 8507106v1 |
| Volume Number | 24 |
| Issue Number | 4 |
| Journal | Archives of environmental contamination and toxicology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AROMATICS Benzo(a)pyrene Carcinoma of lung Coefficient Diesel Fuel Hydrocarbons Liquid Chromatography Lung diseases Malignant Neoplasms Microgram per Kilogram Non-Small Cell Lung Carcinoma Patients Polycyclic Hydrocarbons, Aromatic Structure of parenchyma of lung Tobacco smoke benzo(k)fluoranthene |
| Content Type | Text |
| Resource Type | Article |
