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Measurement of tissue-radiation dosage using a thermal steady-state elastic shear wave.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chang, Sheng-Yi Hsieh, Tung-Sheng Chen, Wei-Ru Chen, Jin-Chung Chou, Chien |
| Copyright Year | 2017 |
| Abstract | A biodosimeter based on thermal-induced elastic shear wave (TIESW) in silicone acellular porcine dermis (SAPD) at thermal steady state has been proposed and demonstrated. A square slab SAPD treated with ionizing radiation was tested. The SAPD becomes a continuous homogeneous and isotropic viscoelastic medium due to the generation of randomly coiled collagen fibers formed from their bundle-like structure in the dermis. A harmonic TIESW then propagates on the surface of the SAPD as measured by a nanometer-scaled strain-stress response under thermal equilibrium conditions at room temperature. TIESW oscillation frequency was noninvasively measured in real time by monitoring the transverse displacement of the TIESW on the SAPD surface. Because the elastic shear modulus is highly sensitive to absorbed doses of ionizing radiation, this proposed biodosimeter can become a highly sensitive and noninvasive method for quantitatively determining tissue-absorbed dosage in terms of TIESW’s oscillation frequency. Detection sensitivity at 1 cGy and dynamic ranges covering 1 to 40 cGy and 80 to 500 cGy were demonstrated. |
| Starting Page | 85001 |
| Ending Page | 85001 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| DOI | 10.1117/1.JBO.22.8.085001 |
| PubMed reference number | 28777836 |
| Journal | Medline |
| Volume Number | 22 |
| Issue Number | 8 |
| Alternate Webpage(s) | https://photonicsforenergy.spiedigitallibrary.org/journalArticle/Download?fullDOI=10.1117/1.JBO.22.8.085001&isResultClick=False |
| Alternate Webpage(s) | https://www.spiedigitallibrary.org/journalIssue/Download?DOI=10.1117/1.JBO.22.8.085001&downloadType=journal+article&fullDOI=10.1117/1.JBO.22.8.085001&isResultClick=True |
| Alternate Webpage(s) | https://doi.org/10.1117/1.JBO.22.8.085001 |
| Journal | Journal of biomedical optics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |