NDLI: A Cross-Machine Comparison of Shear-Wave Speed Measurements Using 2D Shear-Wave Elastography in the Normal Female Breast

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A Cross-Machine Comparison of Shear-Wave Speed Measurements Using 2D Shear-Wave Elastography in the Normal Female Breast

Content Provider	MDPI
Author	O’Flynn, Elizabeth Harris, Emma Sinnatamby, Ruchi Kirby, Anna M. Bamber, Jeffrey C.
Copyright Year	2021
Description	Quantitative measures of radiation-induced breast stiffness are required to support clinical studies of novel breast radiotherapy regimens and exploration of personalised therapy, however, variation between shear-wave elastography (SWE) machines may limit the usefulness of shear-wave speed $(c_{s}$) for this purpose. Mean $c_{s}$ measured in four healthy volunteers’ breasts and a phantom using 2D-SWE machines Acuson S2000 (Siemens Medical Solutions) and Aixplorer (Supersonic Imagine) were compared. Shear-wave speed was measured in the skin region, subcutaneous adipose tissue and parenchyma. $c_{s}$ estimates were on average 2.3% greater when using the Aixplorer compared to S2000 in vitro. In vivo, $c_{s}$ estimates were on average 43.7%, 36.3% and 49.9% significantly greater (p << 0.01) when using the Aixplorer compared to S2000, for skin region, subcutaneous adipose tissue and parenchyma, respectively. In conclusion, despite relatively small differences between machines observed in vitro, large differences in absolute measures of shear wave speed measured were observed in vivo, which may prevent pooling of cross-machine data in clinical studies of the breast.
Starting Page	9391
e-ISSN	20763417
DOI	10.3390/app11209391
Journal	Applied Sciences
Issue Number	20
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-10-10
Access Restriction	Open
Subject Keyword	Applied Sciences Radiology, Nuclear Medicine and Imaging Shear-wave Elastography Shear-wave Speed Radiation-induced Breast Toxicity Tissue Stiffness Cross-machine Comparison
Content Type	Text
Resource Type	Article

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