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Más allá del ecocardiograma en el diagnóstico de la insuficiencia cardiaca
| Content Provider | Semantic Scholar |
|---|---|
| Author | Conde, Ana Muñoz, Miriam Estébanez Hernández, Carmen González Sánchez, David Martí |
| Copyright Year | 2019 |
| Abstract | espanolLa amiloidosis es una enfermedad sistemica causada por la acumulacion extracelular en diferentes tejidos de una proteina mal plegada. Entre los tipos mas frecuentes encontramos la transtiretina (TTR) que se subdivide en dos entidades, la TTR mutada que es hereditaria y la TTR wild-type. Cursa con una clinica heterogenea entre la que destaca la insuficiencia cardiaca restrictiva que supone la principal causa de mortalidad. La amiloidosis cardiaca por transtiretina es una entidad infradiagnosticada en la actualidad y requiere una alta sospecha clinica. Presentamos un caso de un paciente de 84 anos que ingresa en Medicina Interna por un cuadro de insuficiencia cardiaca descompensada. El ecocardiograma y la RM cardiaca muestran signos de miocardiopatia restrictiva secundaria a amiloidosis que se confirma en el estudio histologico de grasa subcutanea y se establece finalmente el tipo de amiloide mediante la gammagrafia con tecnecio-difosfato. Esta entidad precisa un manejo especifico y presenta un pronostico que difiere de otros tipos de insuficiencia cardiaca. EnglishAmyloidosis is a systemic disease caused by the extracellularaccumulation of a misfolded protein in different tissues. Among the most frequent typesof amyloid,we find the transthyretin (ATTR) which is subdivided into two subtypes, the mutated ATTR that is hereditary and the wild-type ATTR. It is characterized by heterogeneous manifestations althoughthe cardiac involvementstands out as the main cause of mortality. Transthyretin cardiac amyloidosis isunderdiagnosed and requires a high clinical suspicion. We present a case of an 84-year-old patient admitted to Internal Medicine becauseof acuteheart failure. The echocardiogram and cardiac MRI show signs of restrictive cardiomyopathy secondary to amyloidosis that is confirmed with the histological study of subcutaneous fat and the type of amyloid is finally established by technetium-diphosphate scintigraphy. This entity requires specific management and has a prognosis that differs from other types of heart failure. |
| Starting Page | 15 |
| Ending Page | 19 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.37536/riecs.2019.4.1.142 |
| Volume Number | 4 |
| Alternate Webpage(s) | https://ebuah.uah.es/dspace/bitstream/handle/10017/37884/mas_roel_RIECS%202019,%20v.%204,%20n.%201.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://riecs.es/index.php/riecs/article/download/142/196 |
| Alternate Webpage(s) | https://doi.org/10.37536/riecs.2019.4.1.142 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
