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Anti Proliferative Properties of Melissa officinalis in Different Human Cancer Cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jahanban-Esfahlan, Akram Modaeinama, Sina Abasi, Mozhgan Abbasi, Mehran Mesgari Jahanban-Esfahlan, Rana |
| Copyright Year | 2015 |
| Abstract | BACKGROUND Medicinal plants, especially examples rich in polyphenolic compounds, have been suggested to be chemopreventive on account of their antioxidative properties. Melissa officinalis L. (MO), an aromatic and medicinal plant, is well known in thios context. However, toxicity against cancer cells has not been fully studied. Here, we investigated the selective anticancer effects of an MO extract (MOE) in different human cancer cells. MATERIALS AND METHODS a hydro-alcoholic extract of MO was prepared and total phenolic content (TPC) and total flavonoid content (TFC) were determined by colorimetric assays. Antioxidant activity was determined by DPPH radical scavenging activity. MTT assays were used to evaluate cytotoxicity of different doses of MOE (0, 5, 20, 100, 250, 500, 1000 μg/ml) towards A549 (lung non small cell cancer cells), MCF-7 (breast adenocarcinoma), SKOV3 (ovarian cancer cells), and PC-3 (prostate adenocarcinoma) cells. RESULTS Significant (P<0.01) or very significant (P<0.0001) differences were observed in comparison to negative controls at all tested doses (5-1000 μg/ml). In all cancer cells, MOE reduced the cell viability to values below 33%, even at the lowest doses. In all cases, IC50 values were below 5μg/ml. The mean growth inhibition was 73.1%, 86.7%, 79.9% and 77.8% in SKOV3, MCF-7 and PC-3 and A549 cells, respectively. CONCLUSIONS Our results indicate that a hydro-alcoholic extract of MO possess a high potency to inhibit proliferation of different tumor cells in a dose independent manner, suggesting that an optimal biological dose is more important than a maximally tolerated one. Moreover, the antiprolifreative effect of MO seems to be tumor type specific, as hormone dependant cancers were more sensitive to antitumoral effects of MOE. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journal.waocp.org/article_31055_629783144d721f49aa830f946b270b09.pdf |
| PubMed reference number | 26320439v1 |
| Volume Number | 16 |
| Issue Number | 14 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | AROMATICS Adverse reaction to drug Alcoholic Neuropathy Alcoholics Carcinoma, Small Cell Cell Survival Flavonoids Inhibitory Concentration 50 Malignant Neoplasms Malignant neoplasm of ovary Melissa officinalis One Thousand Plants, Medicinal Salt-Tolerant Plants Structure of parenchyma of lung adenocarcinoma of the prostate breast adenocarcinoma cancer cell monooxyethylene trimethylolpropane tristearate ovarian neoplasm |
| Content Type | Text |
| Resource Type | Article |
