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Descending modulation of visceral nociceptive transmission from the locus coeruleus/subcoeruleus in the rat
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Limin Tsuruoka, Masayoshi Masako Hayashi, Bunsho Inoue, Tomio |
| Copyright Year | 2008 |
| Abstract | The purpose of the present investigation was to examine whether electrical stimulation in the locus coeruleus/subcoeruleus (LC/SC) could modulate visceral pain evoked by noxious colorectal distention (CRD). Experiments were performed on 40 pentobarbital anesthetized male Sprague-Dawley rats. Extracellular potentials of single L(6)-S(2) spinal neuron were recorded with a carbon filament electrode. CRD (80 mmHg) was produced by inflating a balloon inside the descending colon and rectum. Electrical stimulation of the LC/SC (30, 50 and 70 microA, 100 Hz, 0.1 ms pulses) was delivered either ipsilaterally or contralaterally. Results showed that for 42/62 (68%) short-latency abrupt (SL-A) neurons, all of the short-latency sustained (SL-S) and long-latency (LL) neurons, LC/SC stimulation produced intensity-dependent attenuation of the CRD-evoked discharge. For 10/62 (16%) SL-A neurons, 6/8 (75%) inhibited (INHIB) neurons LC/SC stimulation increased the evoked discharge, for 10/62 (16%) SL-A neurons and 2/8 (25%) INHIB neurons, the evoked discharges were unaffected by the LC/SC stimulation. LC/SC stimulation also had different effects on the spontaneous activities of these neurons. The effects of LC/SC stimulation were the same both ipsilaterally and contralaterally either for the evoked discharges or for spontaneous activities. Following LC/SC lesions, LC/SC stimulation did not inhibit nociceptive responses, whereas inhibitory effects were observed by stimulation of the intact LC/SC contralateral to the recording site. These data suggest that the transmission of visceral pain was under the control of the centrifugal pathways from the LC/SC. |
| Starting Page | 616 |
| Ending Page | 625 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.brainresbull.2008.04.010 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S036192300800172X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S036192300800172X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | http://bmss.ccmu.edu.cn/extra/col1/1224118914.pdf |
| PubMed reference number | 18598853 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.brainresbull.2008.04.010 |
| Journal | Medline |
| Volume Number | 76 |
| Journal | Brain Research Bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
