NDLI: Analysis of a glycinergic inhibitory pathway in the cat retina.

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Analysis of a glycinergic inhibitory pathway in the cat retina.

Content Provider	Semantic Scholar
Author	Wässle, Heinz Schäfer-Trenkler, I. Voigt, Thomas
Copyright Year	1986
Abstract	Incubation of cat retinas with 3H-glycine in vitro, followed by horizontal sectioning and autoradiography, showed labeling of 10-12% of bipolar cells and 45% of amacrine cells. To ascertain the effects of glycine-accumulating bipolar and amacrine cells on the response properties of retinal ganglion cells, in vivo iontophoretic studies were performed in the cat eye. Glycine inhibited all ganglion cells, and this action was blocked by strychnine. Aminophosphonobutyric acid (APB) suppressed ON-ganglion cells, but activated OFF-ganglion cells. The influence of APB upon OFF-ganglion cells could be completely blocked by strychnine. In the mudpuppy, APB suppressed ON-bipolar cells without affecting OFF-bipolar cells and without direct effects on other retinal neurons (Slaughter and Miller, 1981, 1985). If APB has the same mode of action in the cat retina, the present results suggest a glycinergic inhibitory input of the ON-channel upon OFF-ganglion cells.
Starting Page	594
Ending Page	604
Page Count	11
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/6/2/594.full.pdf
PubMed reference number	3950712v1
Volume Number	6
Issue Number	2
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Autoradiography Bipolar Disorder Coloboma of iris Ganglia Ganglion cell Glycine In Vitro [Publication Type] Necturus Retina Retinal Ganglion Cells Sectioning technique Strychnine Thioctic Acid
Content Type	Text
Resource Type	Article

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