Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure.

Content Provider	Semantic Scholar
Copyright Year	1969
Abstract	THE VERTEBRATE RETINA is a POrtiOn Of the central nervous system that is particularly advantageous for study of structural and functional relationships. It is readily accessible, highly ordered, and easily stimulated. It consists of five types of neurons whose perikarya are arranged in discrete layers, and the retinal synapses are all confined to two plexiform layers. Recent studies by electron microscopy have added significantly to our understanding of the synaptic organization of the vertebrate retina (13-15, 30, 35). Retinal neurons are small, however, and recording from single cells in the retina has been difficult. Only from the ganglion cells or their axons have single-unit recordings been routinely made (1, 2, 21, 23, 27-29, 36, 39, 40). The few intracellular recordings obtained from more distal neurons in the retina suggest that many of the cells generate slow, graded potentials (3, 8, 9, 25, 36, 37’) which make extracellular recording difficult to interpret (6). A few years ago, Uortoff (3, 4) showed that it was possible to record intracellularly throughout the retina of the mudpuppy, Necturus maculosus. The nuclei of the cells in Nectuws are extraordinarily large, which considerably increases the size of the cell perikarya. The present paper and the one following present an anatomical and physiological analysis of the Necturus retina. The principles of synaptic organization of the Necturus retina are similar to those of other vertebrates. Accordingly, discussion in this paper will emphasize features of the Necturus retina that are special to it and are particularly relevant to
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Alternate Webpage(s)	http://jn.physiology.org/content/jn/32/3/315.full.pdf
Alternate Webpage(s)	http://neurosci.info/courses/systems/Retina/dowling.werblinl.pdf
PubMed reference number	5787842v1
Volume Number	32
Issue Number	3
Journal	Journal of neurophysiology
Language	English
Access Restriction	Open
Subject Keyword	Abnormal degeneration Anura Axon Bipolar Disorder CNS disorder Cellular Phone Coloboma of iris Dendrites Electron Microscopy Eye Neoplasms Ganglion cell Interneurons Leukemia, B-Cell Macaca Myoxocephalus octodecemspinosus Necturus maculosus Nervous system structure Ninety Nine Primates Retina Retinal Detachment Retinal Pigments Science of Anatomy Seventy Nine Squirrels Synapses Vertebrates anatomical layer electrode horizontal cell
Content Type	Text
Resource Type	Article