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Nuclear expression of BCL10 or nuclear factor kappa B predicts Helicobacter pylori-independent status of early-stage, high-grade gastric mucosa-associated lymphoid tissue lymphomas.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kuo, Sung-Hsin Chen, L. Yeh, Kun-Huei Wu, Ming-Shiang Hsu, Hui-Chen Yeh, Pei-Yen Mao, Tsui-Lien Chen, Chi-Long Doong, Shin-Lian Lin, Jaw-Town Cheng, Ann-Lii |
| Copyright Year | 2004 |
| Abstract | PURPOSE A high percentage of early-stage, high-grade gastric mucosa-associated lymphoid tissue (MALT) lymphomas remain Helicobacter pylori dependent. t(11;18)(q21;q21), a genetic aberration highly predictive of H. pylori-independent status in low-grade gastric MALT lymphoma, is rarely detected in its high-grade counterpart. This study examined whether nuclear expression of BCL10 or nuclear factor kappa B (NF-kappaB) is useful in predicting H. pylori-independent status in patients with stage IE high-grade gastric MALT lymphomas. PATIENTS AND METHODS Twenty-two patients who had participated in a prospective study of H. pylori eradication for stage IE high-grade gastric MALT lymphomas were studied. The expression of BCL10 and NF-kappaB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy. The presence of t(11;18)(q21;q21) was identified by a multiplex reverse transcriptase polymerase chain reaction of the API2-MALT1 chimeric transcript. RESULTS Aberrant nuclear expression of BCL10 was detected in seven (87.5%) of eight H. pylori-independent and in none of 14 H. pylori-dependent high-grade gastric MALT lymphomas (P <.001). All seven patients with nuclear BCL10 expression had nuclear expression of NF-kappaB, compared with only two of 15 patients without nuclear BCL10 expression (P =.002). As a single variable, the frequency of nuclear expression of NF-kappaB was also significantly higher in H. pylori-independent tumors than in H. pylori-dependent tumors (seven of eight [87.5%] v two of 15 [12.3%]; P =.002). The API2-MALT1 fusion transcript was detected in only one (12.5%) of eight H. pylori-independent lymphomas. CONCLUSION Nuclear expression of BCL10 or NF-kappaB is highly predictive of H. pylori-independent status in high-grade gastric MALT lymphoma, and coexpression of these two markers in the nuclei is frequent. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 15337797 |
| Journal | Medline |
| Volume Number | 22 |
| Issue Number | 17 |
| Alternate Webpage(s) | http://eanimal.snu.ac.kr/Aboutus/seminar/%EB%B0%9C%ED%91%9C%EB%85%BC%EB%AC%B8010406.pdf |
| Alternate Webpage(s) | https://doi.org/10.1200/JCO.2004.10.087 |
| Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
