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Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21).
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kuo, Sung-Hsin Chen, L. Mao, Tsui-Lien Doong, Shin-Lian Wu, Ming-Shiang Hsu, Hui-Chen Tzeng, Y. S. Chen, Chi-Long Lin, Jaw-Town Cheng, Ann-Lii |
| Copyright Year | 2005 |
| Abstract | The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-kappaB) was recently found to be closely associated with H pylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P < .001). Nuclear expression of NF-kappaB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P < .001). Further, nuclear translocation of BCL10 and NF-kappaB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-kappaB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21). |
| File Format | PDF HTM / HTML |
| DOI | 10.1182/blood-2005-01-0004 |
| PubMed reference number | 15845895 |
| Journal | Medline |
| Volume Number | 106 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/early/2005/04/21/blood-2005-01-0004.full.pdf?sso-checked=true |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/106/3/1037.full.pdf?sso-checked=true |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2005-01-0004 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
