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Label-free optical biosensing using a horizontal air-slot SiNx microdisk resonator.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lee, Shinyoung Eom, Seok Chan Chang, Jee Soo Huh, Chul Sung, Gun Yong Shin, Jung H. |
| Copyright Year | 2010 |
| Abstract | We demonstrate label-free optical biosensing using a horizontal air-slotted silicon-rich silicon nitride (SiNx) microdisk resonator. Due to the strong confinement of light in the air-slot, a large resonance shift of 6.2 nm is observed upon reaction of the biotin-functionalized disk with a streptavidin solution with concentration of 2.5 μg/ml. Assuming a linear relationship between resonance shift and streptavidin concentration, we estimate the sensitivity to be 2.5 ± 0.2 nm/(μg/ml). Comparing this value with surface sensitivity of 5.7 nm/nm calculated using FDTD simulations, a detection limit of 30 ± 2 ng/ml, is extrapolated. |
| Starting Page | 1315 |
| Ending Page | 1327 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://spl.kaist.ac.kr/file/Published%20Papers/(70)%20Lee_OPEX%20Label-free%20optical%20biosensing%20using%20a%20horizontal%20air-slot%20SiNx%20microdisk%20resonator.pdf |
| PubMed reference number | 20940958v1 |
| Alternate Webpage(s) | https://doi.org/10.1364/OE.18.020638 |
| DOI | 10.1364/OE.18.020638 |
| Journal | Optics express |
| Volume Number | 18 |
| Issue Number | 20 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biotin Diameter (qualifier value) Microgram per Liter Resonator Device Component Revision procedure Scientific Publication Sleep Apnea, Obstructive Streptavidin Tapering - action Tissue fiber silicon nitride wavelength |
| Content Type | Text |
| Resource Type | Article |
