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Circulating free nitrotyrosine in obstructive sleep apnea.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Svatikova, Anna Wolk, Robert A. Wang, Hui Helen Otto, Maria E. Bybee, Kevin A. Singh, Ravinder Jeet Somers, V. K. |
| Copyright Year | 2004 |
| Abstract | Obstructive sleep apnea (OSA) has been increasingly linked to cardiovascular disease, endothelial dysfunction, and oxidative stress, generated by repetitive nocturnal hypoxemia and reperfusion. Circulating free nitrotyrosine has been reported as a novel biomarker of nitric oxide (NO)-induced oxidative/nitrosative stress. Nitrosative stress has been implicated as a possible mechanism for development of cardiovascular diseases. We tested the hypothesis that repetitive severe hypoxemia resulting from OSA would increase NO-mediated oxidative stress. We studied 10 men with newly diagnosed moderate to severe OSA who were free of other diseases, had never been treated for OSA, and were taking no medications. Nitrotyrosine measurements, performed by liquid chromatography-tandem mass spectrometry, were made before and after untreated apneic sleep. We compared free nitrotyrosine levels in these patients with those obtained at similar times in 10 healthy male control subjects without OSA, with similar age and body mass index. Evening baseline nitrotyrosine levels were similar before sleep in the control and OSA groups [0.16 +/- 0.01 and 0.15 +/- 0.01 ng/ml, respectively, P = not significant (NS)]. Neither normal nor disturbed apneic sleep led to significant changes of plasma nitrotyrosine (morning levels: control group 0.14 +/- 0.01 ng/ml; OSA group 0.15 +/- 0.01 ng/ml, P = NS). OSA was not accompanied by increased circulating free nitrotyrosine either at baseline or after sleep. This observation suggests that repetitive hypoxemia during OSA does not result in increased NO-mediated oxidative/nitrosative stress in otherwise healthy subjects with OSA. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpregu.physiology.org/content/ajpregu/287/2/R284.full.pdf |
| PubMed reference number | 15142836v1 |
| Volume Number | 287 |
| Issue Number | 2 |
| Journal | American journal of physiology. Regulatory, integrative and comparative physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 3-nitrotyrosine Biological Markers Body mass index Cardiovascular Diseases Hypoxia Microgram per Liter Nitric Oxide Oxidative Stress Patients Reperfusion Therapy Sleep Apnea Syndromes Sleep Apnea, Obstructive Tandem Mass Spectrometry |
| Content Type | Text |
| Resource Type | Article |
