NDLI: Non-quantal acetylcholine release at mouse neuromuscular junction: Effects of elevated quantal release and aconitine

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Non-quantal acetylcholine release at mouse neuromuscular junction: Effects of elevated quantal release and aconitine

Content Provider	Semantic Scholar
Author	Yu, Shan Ping Kloot, William Van Der
Copyright Year	1990
Abstract	The rate of non-quantal acetylcholine (ACh) release was estimated at the mouse neuromuscular junction by observing the effect of (+)-tubocurarine on endplate membrane potential or current in preparations pretreated with an irreversible anti-acetylcholinesterase (anti-AChE). Voltage clamping was an effective method for measuring non-quantal release. Non-quantal release was markedly inhibited by 10 microM aconitine. Non-quantal release was not significantly increased by 10 microM dihyroouabain (DHO). (It has been reported that ouabain increases the leak). Non-quantal release was roughly doubled following exposure to hypertonic solution or to elevated K(+)-solution. This is in accord with the hypothesis that the leak is by way of ACh transporters incorporated into the terminal membrane following exocytosis, but other interpretations remain to be tested.
Starting Page	111
Ending Page	116
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(90)90128-V
PubMed reference number	2290606
Journal	Medline
Volume Number	117
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409090128V
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409090128V?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2890%2990128-V
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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