NDLI: [Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].

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[Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].

Content Provider	Semantic Scholar
Author	Xu, Li-Min Zhang, Deng-Hai Yang, Chun-Xin Liu, Xu-Hui Uzan, Geroges Qin, Wan-Zhang
Copyright Year	2007
Abstract	OBJECTIVE Increasing of adhesion between leukemia cells and endothelial cells during all-trans retinoic acid (ATRA) treatment plays an important role in retinoic acid syndrome. This work observed the effects of tripterine on this ATRA-caused increasing in adhesion. METHODS The effects of tripterine on ATRA-induced expressions of adhesive molecules in acute promyelocytic leukemia cell line NB4 and human umbilical vascular endothelial cells (HUVEC) were detected by flow cytometry. The effects of tripterine on adhesion between ATRA-treated NB4 and HUVEC were determined by adhesive assays. RESULTS ATRA caused remarkable elevation of intercellular adhesion molecule-1 (ICAM-1) in NB4 cells, which could be significantly reduced by tripterine (P<0.01). The expressions of E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and ICAM-1 in HUVEC were elevated by conditioned medium from ATRA-induced NB4 (ATRA-NB4-CM) (P<0.01), and inhibited by tripterine with inhibition rates being 25.3%, 42.4% and 61.0% respectively. ATRA increased the adhesion between NB4 and HUVEC, which was reversed completely by tripterine. CONCLUSION Tripterine can inhibit ATRA-caused adhesion between leukemia cells and endothelial cells, and it might be a potential agent for treating retinoic acid syndrome.
Starting Page	270S
Ending Page	276S
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jcimjournal.com/articles/publishArticles/pdf/200771136431.pdf
PubMed reference number	17498488v1
Volume Number	5
Issue Number	3
Journal	Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Language	English
Access Restriction	Open
Subject Keyword	Acute Promyelocytic Leukemia Adhesives Cell Adhesion Culture Media, Conditioned E-Selectin Intercellular adhesion molecule 1 Leukemia, B-Cell Retinoic acid syndrome Selectins Thinonoma atra Tretinoin Umbilicus (Anatomy) tripterine
Content Type	Text
Resource Type	Article

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